Kohji Okamoto Selected Research

Disseminated Intravascular Coagulation

6/2022	Prognostic value of serum high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study.
1/2022	Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis.
12/2021	An evaluation of the Japanese Society on Thrombosis and Hemostasis criteria for disseminated intravascular coagulation as a predictor of prognosis in patients with infection.
2/2021	Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa.
1/2021	Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis.
1/2021	Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients.
1/2020	Analysis of the association between resolution of disseminated intravascular coagulation (DIC) and treatment outcomes in post-marketing surveillance of thrombomodulin alpha for DIC with infectious disease and with hematological malignancy by organ failure.
1/2020	Severe Antithrombin Deficiency May be Associated With a High Risk of Pathological Progression of DIC With Suppressed Fibrinolysis.
1/2020	The significance of disseminated intravascular coagulation on multiple organ dysfunction during the early stage of acute respiratory distress syndrome.
11/2019	Identifying Sepsis Populations Benefitting from Anticoagulant Therapy: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model.

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Kohji Okamoto Research Topics

Disease

35	Disseminated Intravascular Coagulation 06/2022 - 09/2003
21	Sepsis (Septicemia) 01/2022 - 12/2008
15	Thrombosis (Thrombus) 06/2022 - 09/2003
11	Infections 12/2021 - 01/2005
8	Acute Cholecystitis 01/2018 - 01/2012
7	Cholangitis 01/2018 - 09/2012
6	Communicable Diseases (Infectious Diseases) 02/2021 - 08/2011
6	Wounds and Injuries (Trauma) 01/2021 - 09/2003
6	Neoplasms (Cancer) 06/2017 - 06/2003
5	Hemorrhage 02/2021 - 01/2010
5	Multiple Organ Failure (MODS) 02/2021 - 03/2009
4	Septic Shock (Toxic Shock Syndrome) 11/2020 - 11/2019
4	Inflammation (Inflammations) 01/2018 - 11/2007
3	Critical Illness (Critically Ill) 05/2018 - 01/2005
3	Cholecystitis 01/2018 - 01/2013
3	Hepatocellular Carcinoma (Hepatoma) 03/2017 - 06/2004
2	Diabetes Mellitus 11/2022 - 01/2020
2	Frailty 08/2021 - 01/2021
2	Hematologic Neoplasms (Hematological Malignancy) 01/2020 - 08/2011
2	Carcinoma (Carcinomatosis) 03/2017 - 06/2003
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2016 - 10/2008
2	Stomach Neoplasms (Stomach Cancer) 04/2014 - 01/2014
2	Abdominal Pain (Pain, Abdominal) 01/2014 - 01/2013
2	Fever (Fevers) 01/2013 - 10/2012
2	Endotoxemia 07/2009 - 10/2008
2	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2008 - 11/2007
1	Abscess 11/2022
1	Appendicitis 11/2022
1	Intraoperative Complications 11/2022
1	Pancreatitis 10/2022
1	Hyperglycemia 10/2021
1	Surgical Wound Infection 07/2021
1	Hematologic Diseases (Blood Diseases) 02/2021
1	Acute Lung Injury 01/2020
1	Hypoglycemia (Reactive Hypoglycemia) 01/2020
1	Heart Failure 01/2020
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2020
1	Hypothermia 01/2019
1	Intraabdominal Infections 05/2018
1	Hypersensitivity (Allergy) 05/2018
1	Fibrosis (Cirrhosis) 01/2018

Drug/Important Bio-Agent (IBA)

36	Dacarbazine (DIC)FDA LinkGeneric 06/2022 - 09/2003
10	ThrombomodulinIBA 01/2022 - 10/2008
8	Anti-Bacterial Agents (Antibiotics)IBA 10/2022 - 10/2012
8	AntithrombinsIBA 01/2022 - 08/2011
4	HMGB1 Protein (HMG1)IBA 06/2022 - 10/2008
4	Fibrinogen (Factor I)FDA Link 02/2021 - 01/2008
3	AnticoagulantsIBA 01/2022 - 01/2010
3	Thrombin FDA Link 01/2016 - 10/2008
3	Hemostatics (Antihemorrhagics)IBA 01/2013 - 11/2007
2	Proteins (Proteins, Gene)FDA Link 06/2022 - 07/2009
2	CreatinineIBA 01/2020 - 06/2003
2	CytokinesIBA 01/2016 - 07/2009
2	antithrombin III-protease complexIBA 01/2013 - 07/2009
2	FibrinIBA 11/2012 - 09/2012
2	fibrinmonomerIBA 09/2012 - 08/2011
2	Prothrombin (Factor II)IBA 06/2012 - 01/2011
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2004 - 06/2003
2	MidkineIBA 06/2004 - 06/2003
2	Heparin (Liquaemin)FDA LinkGeneric 06/2004 - 06/2003
1	C-Reactive ProteinIBA 11/2022
1	Histones (Histone)IBA 06/2022
1	Hypoglycemic Agents (Hypoglycemics)IBA 10/2021
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2021
1	Polymyxin B (Aerosporin)FDA LinkGeneric 11/2020
1	EndotoxinsIBA 11/2020
1	Virulence Factors (Pathogenicity Factors)IBA 01/2020
1	SteroidsIBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Blood Glucose (Blood Sugar)IBA 01/2020
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020
1	BilirubinIBA 01/2020
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2020
1	ElementsIBA 11/2019
1	Ciprofloxacin (Cipro)FDA LinkGeneric 05/2018
1	Cefepime (Maxipime)FDA LinkGeneric 05/2018
1	LactamsIBA 05/2018
1	Aztreonam FDA LinkGeneric 05/2018
1	Doripenem FDA Link 05/2018
1	Imipenem Drug Combination Cilastatin (Primaxin)FDA Link 05/2018
1	GlycopeptidesIBA 05/2018
1	Tazobactam Drug Combination Piperacillin (Zosyn)FDA LinkGeneric 05/2018
1	Meropenem (Merrem)FDA LinkGeneric 05/2018
1	Metronidazole (Metric)FDA LinkGeneric 05/2018
1	CephamycinsIBA 05/2018

Therapy/Procedure

15	Therapeutics 01/2022 - 01/2010
6	Length of Stay 08/2021 - 01/2013
6	Laparoscopic Cholecystectomy 01/2018 - 12/2003
3	Critical Care (Surgical Intensive Care) 01/2020 - 01/2008
3	Cholecystectomy 01/2013 - 07/2012
2	Conservative Treatment 11/2022 - 10/2013
2	Patient Care Bundles 01/2022 - 11/2019
2	Resuscitation 01/2021 - 06/2019
2	Hepatectomy 03/2017 - 01/2016
1	Appendectomy 11/2022
1	Enteral Nutrition (Feeding, Tube) 10/2022
1	Glycemic Control 10/2021
1	Hemoperfusion 11/2020
1	Mechanical Ventilators (Ventilator) 01/2019
1	Central Venous Catheters 11/2018